13.8 Billion years ago, something happened - the Big Bang - which set in motion our expanding Universe. Through the systematic process of science, humanity has managed in a very short time to piece together a comprehensive story of our Universe. In 2016 the vital statistics of the universe - its composition, size, density, shape, and age – are known to remarkable accuracy. But the job is nowhere near done. In my lecture, I will discuss what we know, and what we don't know about the Universe, and try to guess likely new areas for discovery in the years and decades to come.