Resistance to antibiotics and the spread of antibiotics’ metabolites are severe problem in contemporary medicine. In addition to structures of complexes of eubacterial-ribosomes with antibiotics paralyzing them that illuminated common pathways in the modes of antibiotics inhibitions, synergism, differentiation and resistance, recent structures of ribosome from a multi-resistant pathogenic bacteria identified features that can account for species-specific diversity in infectious-diseases susceptibility. Careful analysis and comparisons to ribosomes from benign bacteria indicated novel paths for the design of environmental-friendly degradable, species-specific antibiotics, thus also preserving the microbiome.