Abstract
Not satisfied with nature’s vast repertoire of chemistry, I want to create new protein catalysts and expand the space of enzyme functions. Nature’s most powerful biological design process, evolution, can be used to explore the universe of possible catalysts and move into a more sustainable future in which chemistry, including human-invented chemistry, will be genetically encoded. Using evolution to optimise existing enzymes and invent new ones allows us to circumvent our profound ignorance of how sequence encodes function.
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